
Bone Marrow Aspirate Concentrate (BMAC)
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The concentrated fraction of aspirated bone marrow containing the highest amount of platelets, growth factors, bioactive molecules and stem cells
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Provides a concentrated blend of regenerative cells and signaling molecules directly into injured tissue
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Greatest regenerative potential of autologous Orthobiologic interventions
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BMAC 101

Greatest
Regenerative Ability
* Due to the presence of stem cells and growth factors & their complex role in tissue healing
- Mesenchymal Stem Cells (MSCs) are multipotent progenitor cells
- Release their own growth factors & signaling molecules and interact with those inside damaged tissue
- Significant role not only in reducing pain and inflammation, but in tissue healing at the cellular level

Cell Differentiation & Repopulation
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MSCs have the ability to proliferate (self-renew) and differentiate (specialize) into specific cell types (including chondrocytes- cartilage cells & tenocytes- tendon cells)
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This replaces the existing damaged cells
Paracrine Action
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Secrete their own trophic factors (growth factors & cytokines) to support cell growth and survival
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Induce the release of other cells’ cytokines, growth factors & bioactive molecules
Immunomodulation
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Neutralize pro-inflammatory mediators in damaged tissue to prevent further breakdown
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Regulated immune cell expression & changes to the chemical microenvironment corrects the anabolic/catabolic imbalance that drives degenerative joint and tendon disease
Various Pathways for Diverse Tissue Healing
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MSC osteogenesis leads to the development of new bone, which holds promise for treating fractures, bone defects, and nonunions. MSC-based therapies rely on pathways such as BMP, Wnt, and Runx2-associated mechanisms to drive bone formation, offering a renewable source for bone graft substitutes and improved orthopedic outcomes.
Image source: https://doi.org/10.1016/j.tice.2024.102380
MSCs can differentiate into chondrocytes, enabling the generation of cartilage tissue. This is critical for treating cartilage defects and osteoarthritis, conditions with poor intrinsic healing abilities. Signaling pathways such as TGF-β/Smad and key transcription factors like SOX9 drive this process, making it possible to engineer cartilage for joint repair.
Cartilage
Chondrogenic Differentiation
Bone
Osteogenic Differentiation
Tendon

Through the tenogenic route, MSCs become tendon-forming cells, aiding the regeneration of tendons, which are prone to slow and incomplete healing. Growth factors like TGF-β and CTGF guide MSCs through staged differentiation, enhancing the formation and functional properties of engineered tendon tissue for effective defect repair.
Image Source: https://doi.org/10.1155/2023/3656498
Tenogenic Differentiation

What Happens Inside Joints after BMAC Injection?
Microscopic Reactions
Initiation of healing cascade in the joint space
Significant Changes
Joint spaces increased
Pain scores decreased
* Radiographic improvement in arthritis severity
* No disease progression
Pre-injection
Post-injection


* Statistically significant decrease in pain scores that was maintained over time
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NO complications at harvest site or injection site
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BMAC is a safe, effective, and potentially durable treatment for recalcitrant non/insertional Achilles tendinopathy


Arthrex Angel BMA System
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The system uses a simple, outpatient procedure to harvest bone marrow, reducing patient discomfort and procedure risk while allowing patients to return home the same day.
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Precise adjustment of platelet, leukocyte, and erythrocyte concentrations, ensuring tailored PRP or BMAC formulations for individual patient needs.
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BMAC contains high concentrations of regenerative cells (including stem cells and progenitor cells) that promote tissue repair, boost natural healing, and support growth of new tissue - especially valuable for tendons, cartilage, and joint injuries.
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Automated design features single-button operation and proprietary sensor technology, ensuring efficiency and safety while reducing variability in results.
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Studies show the Angel system produces a more concentrated platelet output than other systems, which has been shown to provide a more robust healing response.
How It's Done


1. Marrow Aspiration
- Bone marrow aspirate (BMA) is collected from the back of the hip bone at a location called posterior superior iliac spine (PSIS)
- Once aspirated, the BMA is transferred to the processing system
2. Centrifugation & Cytometric Separation
- Completed simultaneously
- As the BMA spins, a 3T light sensor separates the marrow components according to their size
3. Collection
- The processing system automatically collects the injection in a sterile syringe
- When complete, the result is a BMAC injection rich in stem cells, platelets & growth factors
What The Research Shows Us:
The Big Picture:
Lasting pain relief
Better function
Improved quality of life
Without the need for surgery or significant downtime.







